Nutmeg Extract Alters Mitochondrial Genes Regulation of Skeletal Muscle Fibers in Aging Rats

Nutmeg as one of Indonesia native plants has already been used widely in herbal treatment. It demonstrated that nutmeg presents activities related to mitochondria functions. potentially the effect peroxisome proliferator activated receptors Υ (PPAR Υ) which contributes myogenesis, and may alters mitochondrial homeostasis respiration biogenesis. In this study, how extract oxidative process skeletal muscle aging rats was explored. Twenty Wistar male aged 80 weeks old were divided into two groups (control treatment). administered for 12 using a gavage. After that, soleus muscles collected, weighted, frozen, stored at -800C until used. observed increase COX1 (1.9 folds, p<0.01), COX2 (1.6 p<0.05), COXIV (2.8 p<0.01) gene expressions, parallel with increased protein carbonyl levels (1.5 p<0,01). treatment also significantly expressions antioxidant endogen COQ7 (2 p<0,01) PDSS2 muscle. Taken together, improve respiratory type I